Considering that GA21 corn has already been well characterized biochemically and functionally in relation to the transformation event; Considering that the possibility of the protein again interfering with metabolic/functional pathways and/or relevant structures is null, considering the morphology of the plant, its agronomic performance, its biochemical composition, nutritional content and digestibility; Considering that the possibility of transgenics causing inadvertent genetic changes in the transgenic plant (silencing or over-expression of endogenous genes) is very low and, if these changes occur, it will not imply adverse effects either to the plant, humans or animals in view of the exposed in the previous item; ; Considering the nutritional and compositional equivalence of GA21 maize compared to its conventional isogenic version, no metabolite of GA21 maize has a potential to concentrate in the food chain, beyond that already expected by conventional maize widely cultivated. In studies of acute oral toxicity in mice performed with the EPSPS protein, it was observed that the EPSPS protein did not present an acute toxic effect to these animals at the highest dose tested. No test substance related mortality occurred during the study and no clinical signs attributable to the test substance were observed.